New energy-generation methods could enable creation of entirely new organisms
March 29, 2023 -- Developing biologically realistic energy-generation methods that mimic natural processes could pave the way for the creation of entirely new organisms or biomaterials, according to a study published on Tuesday in Biophysics Reviews. Read More
Beckman Coulter, Sciex collaborate on high-throughput screening workflows
February 27, 2023 -- Life science analytical technologies company Sciex on Monday announced a collaboration with Beckman Coulter Life Sciences to provide comprehensive workflows for high-throughput screening; high-throughput absorption, distribution, metabolism, and excretion (HT-ADME); and synthetic biology studies. Read More
Nanozyme approach targets fungal infection
May 31, 2023 -- A nanozyme-based robotics approach could allow doctors to target and kill fungal pathogens at the sites of infection, according to a group at the University of Pennsylvania. Read More
Stem cell therapy targets brain metastatic melanomas
May 31, 2023 -- Twin stem cells acting in unison may activate the immune system to suppress metastatic melanoma tumor growth in the brain, according to Department of Defense-funded research, published Wednesday in Science Translational Medicine. The procedure prolonged survival in preclinical trials on mice, indicating that locally delivered immunotherapies may be beneficial in brain metastases treatment. Read More
FDA approves first topical gene therapy for treatment of wounds in patients with dystrophic epidermolysis bullosa
May 19, 2023 -- The U.S. Food and Drug Administration (FDA) said on Friday it has approved Vyjuvek, a herpes-simplex virus type 1 (HSV-1) vector-based gene therapy, for the treatment of wounds in patients six months of age and older with dystrophic epidermolysis bullosa (DEB) and with mutations in the collagen type VII alpha 1 chain (COL7A1) gene. Read More
Revvity, AstraZeneca ink license agreement for next-gen base editing tech
May 19, 2023 -- Revvity this week announced a nonexclusive license agreement with AstraZeneca for the technology underlying a next-generation modular gene editing platform. Read More
Chemical compound stimulates nerve regeneration, protects heart tissue
May 24, 2023 -- Researchers have identified a compound that can stimulate nerve regeneration after injury, as well as protect cardiac tissue from the type of damage seen in heart attacks. The study, published Wednesday in Nature, identified a chemical compound called 1938, which activates the signaling pathway of phosphoinositide 3-kinase (PI3K), an enzyme that helps control cell growth. Read More
Bacterial reaction to antibiotics revealed within minutes
May 22, 2023 -- A simple-to-use method reveals bacterial reaction to antibiotics in only five minutes. Read More
Cryo-electron microscopy sheds light on key step in replication of SARS-CoV-2
May 31, 2023 -- Researchers have used cryo-electron microscopy (cryo-EM) to visualize a critical step in the replication of SARS-CoV-2, generating insights that could inform the development of COVID-19 drugs. Read More
COVID-19’s ‘long tail’ analyzed at European rheumatology congress
May 31, 2023 -- Researchers have found that people with inflammatory rheumatic diseases show no increased susceptibility to long COVID. This and other studies are being presented at the European Alliance of Associations for Rheumatology (EULAR) 2023 Congress in Milan from May 31 to June 3. Read More
HIV nanoparticle vaccine induces strong T-cell responses in early-phase clinical trial
May 26, 2023 -- An HIV nanoparticle vaccine has induced strong T-cell responses in a first-in-human clinical trial, marking a step toward the development of a product that protects against the virus. Read More
New antibiotic targets deadly hospital superbug
May 25, 2023 -- Scientists used artificial intelligence (AI) to discover a promising antibiotic that may help doctors target Acinetobacter baumannii, a deadly, drug-resistant pathogen that often strikes vulnerable hospital patients. The study, published Thursday in the journal Nature Chemical Biology, identified the antibacterial compound abaucin in response to the urgent need for new ways to treat A. baumannii infection. Read More
Single-cell RNA sequencing data reveals T cells linked to cancer immunotherapy resistance
May 30, 2023 -- Single-cell RNA sequencing data has revealed an immune signature associated with non-responses to checkpoint inhibitors that may be a driver of resistance to immunotherapy. Read More
Gene editing tool may reduce antimicrobial resistance spread
May 26, 2023 -- A tool that could help reduce the spread of antimicrobial resistance shows early promise. In an article published Thursday in Microbiology, researchers describe the use of CRISPR technology to eliminate resistance in a wide range of bacteria. Read More
Clinical trial begins for universal flu vaccine candidate
May 16, 2023 -- Researchers at NIH’s National Institute of Allergy and Infectious Diseases (NIAIDs) have developed an experimental universal influenza vaccine. Read More
Biomarker predicts response to chemo-immunotherapy in lung cancer patients
May 15, 2023 -- Researchers have found a biomarker that provides an early indication of whether a patient is responding to chemo-immunotherapy. Read More
Researchers map RNA to inform selection of stem cells for therapeutic applications
May 12, 2023 -- Creating maps of the RNA inside cells could improve cell therapies by enabling the isolation of subsets of cells with similar characteristics, according to a study published Friday in Cell Reports Methods. Read More
Bio-Techne, Lunaphore partner to develop a fully automated spatial multiomics workflow
April 17, 2023 -- Bio-Techne and Lunaphore on Monday announced a strategic partnership to develop a fully automated spatial multiomics workflow with same-slide hyperplex detection of protein and RNA biomarkers. Read More
Scientists create cell atlas of developing human lung
December 9, 2022 -- Researchers from the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute, the Gordone Institute at the University of Cambridge, and collaborators have created a spatiotemporal cell atlas of the developing human lung. From the mapping, they have identified 144 cell states in the early stages of life and their interactions in new detail. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
December 2, 2022 -- Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
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