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Scientists uncover viral vectors that cross the blood-brain barrier
Using a "directed-evolution" strategy in mice and macaques, scientists at the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard have identified adeno-associated viruses (AAVs) that cross the blood-brain barrier, advancing efforts to develop neurological disease gene therapies.
Researchers expand CRISPR-based genome engineering toolbox
North Carolina State University researchers have expanded the CRISPR-based gene editing toolbox with new DNA integrases that have potential applications for biotechnology and therapeutics.
Penn researchers create adrenal gland organoid using stem cells
A research team, led by the University of Pennsylvania's School of Veterinary Medicine, has used stem cells to grow an organoid in a petri dish with the characteristics and functions of a human fetal adrenal gland.
CRISPR-Cas9 gene editing links RNA-binding protein to immunotherapy resistance
Using CRISPR-Cas9 gene editing, Swiss researchers have provided evidence that expression of an RNA-binding protein helps tumors to evade the immune system.
Cell-penetrating peptide conjugate gets chemotherapy across blood-brain barrier in mice
A macrocyclic cell-penetrating peptide conjugate has enabled a cisplatin prodrug to cross the blood-brain barrier (BBB) in mice, increasing survival rates and providing a potential pathway for treating humans with brain cancer.
Rapidly generated artificial enzymes inhibit COVID-19 infection in preclinical tests
Artificial enzymes targeting the SARS-CoV-2 genome can inhibit viral infection, pointing to a new way to rapidly develop treatments for emerging biological threats such as COVID-19.
Immunosuppressive pathway offers explanation for failure of TIGIT clinical trials
Albert Einstein College of Medicine scientists in a new analysis of the immunosuppressive KIR2DL5/PVR pathway provide a potential explanation for why anti-TIGIT therapies have failed in clinical trials.
Fentanyl vaccine stops opioid entering the brain in rats, clearing path to human studies
A fentanyl vaccine has generated antibodies against the potent synthetic opioid in rats, pointing to a way to address opioid use disorder in humans.
Multiplexed 'CAR Pooling' accelerates evaluation of anticancer cell therapy receptors
Researchers have developed a new method for comparing massive numbers of CAR T cells, each with slightly different molecular features, to determine which is most effective and long-lasting against cancer.
Proteomic signature improves detection of hard-to-identify form of prediabetes
Testing for a three-protein signature in the blood could improve the detection of a form of prediabetes, according to research published November 10 in the journal
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