Precision BioSciences highlights hepatitis B virus drug research

By The Science Advisory Board staff writers

May 19, 2022 -- Precision BioSciences is highlighting new research showing that its gene editing drug candidate targeting the hepatitis B virus (HBV) achieved an 85% reduction in covalently closed circular DNA (cccDNA) and a 77% reduction in hepatitis B surface antigen (HBsAg) in HBV-infected primary human hepatocytes (PHH).

Published online in Molecular Therapy, "Targeting the Hepatitis B cccDNA with a Sequence-Specific Arcus Nuclease to Eliminate Hepatitis B Virus In Vivo," shows Precision BioScience's potential drug candidate PBGENE-HBV used in conjunction with its Arcus platform may eliminate virus persistence in patients with chronic hepatitis B.

The researchers evaluated Arcus in vivo by developing novel mouse and non-human primate models that used an episomal adeno-associated virus (AAV) containing a portion of the HBV genome to serve as a surrogate for cccDNA. A lipid nanoparticle containing Arcus mRNA was administered and in addition to the 85% decrease in the cccDNA surrogate in both episomal models, the researchers noticed a 96% reduction of HBsAg in mice. In addition, the optimized specificity of the Arcus nuclease completely prevented detectable chromosomal translocations in the PHH model, according to Precision BioSciences.

The research was conducted in collaboration with Gilead Sciences and Acuitas Therapeutics.

Precision BioSciences presents preclinical data for gene editing therapies
Precision BioSciences is scheduled to display preclinical data for its Arcus-based gene editing studies at the American Society of Gene & Cell Therapy’s...
Precision and Iecure ink collaboration deal
Precision BioSciences and Iecure have entered a license and collaboration agreement to develop gene editing therapies.
Precision BioSciences reacquires rights to allogeneic CAR T programs
Precision BioSciences has entered into an agreement to reacquire global rights to all chimeric antigen receptor (CAR) T partnered programs covered under...
Precision BioSciences demonstrates long-term efficacy of genome editing
Precision BioSciences has demonstrated the use of its Arcus genome editing platform to achieve long-term stable reduction of low-density lipoprotein cholesterol...
Precision BioSciences nabs patent for CAR construct tech
Precision BioSciences has received a notice of allowance from the U.S. Patent and Trademark Office for patent application, No. 16/908, 030. The patent...

Copyright © 2022 scienceboard.net


Conferences
Microscopy and Microanalysis Meeting
July 31 - August 4
Portland, Oregon United States
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter